Effect of [+] -limonene on the percutaneous absorption of naproxen from pluronic F127 gels in rabbits

ABSTRACT

In this work, the percutaneous absorption of naproxen in rabbits was investigated and compared with its in vitro release. The effect of incorporation of [+]-limonene [1-3%] as penetration enhancer on in vitro release of drug from gels and percutaneous absorption was studied using pluronic F127 as a gel base model. Percutaneous absorption was evaluated by determining the serum concentration of naproxen in rabbit's blood. The area under the curve and Cmax in plasma were also calculated. It was proved that the in vitro drug release and its percutaneous absorption were functions of the concentration of [+]-limonene. A significant increase in percutaneous absorption was obtained in the presence of enhancer