Utility of potassium iodate for the estimation of lornoxicam, meloxicam and sulbutiamine in pharmaceutical formulations

ABSTRACT

In this study, a simple and accurate method was described for the determination of lornoxicam, meloxicam and salbutiamine. The method involved the oxidation of drugs with potassium iodate in acidic medium with the liberation of iodine. The liberated iodine was extracted into cyclohexane and the absorbance was measured at 520 nm. The effect of different experimental parameters on the development of the color was studied [the concentration of the reagent, temperature and reaction time]. The method was applicable over a concentration range of 0.10-0.50, 0.05-0.30 and 0.05-0.40 mg ml-1 for lornoxicam, meloxicam and salbutiamine, respectively. The proposed method was successfully applied to the determination of the studied drugs in bulk powder and in the pharmaceutical dosage forms. The validity of the method was assessed by applying the standard addition technique