Assessment of the role of soluble intracellular adhesion molecule-1 [sICAM-1] in the pathogenesis and as a marker of disease severity in different stages of human schistosomiasis and toxoplasmosis

ABSTRACT

The role of soluble intracellular adhesion molecule 1 [sICAM-1] in the pathogenesis and its relevance to disease severity was assessed in different stages of human infection with S. mansoni, S. hematobium and T. Gondii. The levels of sICAM-1 obtained in the current study, correlated with disease severity degree of cell destruction and type of immune response. Highest sICAM-1 levels were observed in only two groups [hepatosplenic schistosomiasis and patients with mixed active S. Hematobium and T. gondii infections], while the other two groups [separate cases of active S. hematobium infection or latent T. Gondii infection] showed no significant rise in sICAM-1 levels