Effect of occupational lead-exposure on blood pressure, serum aldosterone level and plasma renin activity

ABSTRACT

The present study aimed to investigate the association between occupational lead-exposure and elevated blood pressure as well as serum aldosterone level and plasma renin activity as parameters affecting blood pressure. Fifty occupationally lead-exposed [16 males and 34 females] and 50 non-exposed [15 males and 34 females] workers were selected after the application of certain exclusion criteria. All workers were admitted to complete clinical examination including standard blood pressure measurement. Also, blood lead level, serum aldosterone concentration and plasma reran activity were estimated. The results of both occupationally lead-exposed males and females demonstrated no significant differences regarding age, work duration, systolic and diastolic blood pressures when compared with occupationally non- exposed males and females, respectively. In addition, occupationally lead-exposed males and females revealed a significant increase in blood lead level and serum aldosterone concentration compared with controls. Moreover, plasma renin activity is significantly decreased among the lead-exposed male workers; while it is significantly increased among the lead-exposed female workers in comparison with the controls