Prokinetic effect of erythromycin on contractility of an isolated strip of rabbit's intestine compared with neostigmine and metoclopramide

ABSTRACT

Intestinal hypomotility is a major problem after surgery on gastrointestinal tract and in certain conditions. Prokinetic effect of erythromycin on ILEAL contractility on an isolated strip of rabbit's intestine was compared with that of neostigmine and metoclopramide. Effect of neostigmine is highly significant [P > 0.001] in increasing contractility in intestinal muscle strips Metoclopramide effectively increased contractility [P > 0.1] and erythromycin also significantly [P > 0.05] improved contractility. This study proved that erythromycin is a potent Prokinetic agent, which can be useful in conditions associated with gastrointestinal hypomotility