Lipid peroxidation and glutathione redox system in human bladder tissues infected with schistosoma haematobium

ABSTRACT

The present study was carried on human bladder tissues infected with schistosoma haematobium to demonstrate the effects of schistosomiasis on lipid peroxidation and gluathione redox system. Bladder tissue samples were collected from 15 individuals free of schistosomiasis infection and 13 individuals infected with schistosomiasis. Schistosomal bladder specimens were histologically verified by the presence of schistosomal haematobium ova and schistosomal cystitis in bladder mucosa. The biochemical analysis of infected bladder tissues revealed that thio-barbituric acid reactant substances [TBARS], an intermediate product of the oxidation of polyunsaturated fatty acids, increase significantly by + 125% [P < 0.001]. On the other hand, the levels of reduced glutathione [GSH] and the activity of glutatione reductase decreased significantly by 57% [P < 0.01] and - 40% [P<0.001] respectively. Also, the activity of glutathione S - transferase [GST] increased significantly by + 89% [P<0.001]. In conclusion, these results indicate that schistosoma haematobium infection of human bladder tissues induce marked lipid peroxidation damage due to disruption of glurathione redox system