genotoxicity, hepatotoxicity and nephrotoxicity of parcetamol in albino rats

ABSTRACT

This study aimed to shed light on genotoxic, hepatotoxic and nephrotoxic effects of paracetamol. Serum levels of urea, creatinine, alanine amino transferase [ALT], aspirate amino transferase [AST] and alkaline phosphatase were detected after exposure to a high dosage of paracetamol for two weeks. Rats were sacrificed and hepatic and renal tissues were examined by electron microscope to evaluate hepatic and renal toxicity and bone marrow cells were examined for chromosomal abnormalities as an indicator of cytogenic toxicity