Distributions of some insecticides in body fluids and tissues n decedents intoxicated with these chemicals

ABSTRACT

This paper described the body fluids and tissue distribution of four insecticides; one belongs to organochlorine compounds [endosulfan] and three organophosphate insecticides [malathion, chlorpyrifos and diazinon], in four suicidal human cases in Kuwait, who died after ingestion of insecticidal preparations containing these chemicals. The cases were autopsied and distribution of these chemicals were studied in stomach contents, blood, urine, bile and different tissues. Gas chromatography ion trap detector [GC-ITD] was used as analytical tool for the identification and quantitation of insecticides during this work. The study revealed higher concentrations of these insecticides in the stomach contents. Higher concentrations of malathion and endosulfan were detected in bile. Diazinon and chlorpyrifos were found at higher level in spleen. The least amount of these insecticides was recorded in muscle tissues