Comparative study of the toxic and histopathological effects of domestic butane and town gases mice

ABSTRACT

This work aimed to study pathological changes in different parenchymatous organs of mice acutely exposed to different concentrations of butagas and town gas. It was conducted on 35 mice divided into seven groups of five mice each, one group acted as a control. The animals were decapitated and blood samples were taken to detect level of COHb. Brain, heart, lungs, liver and kidneys were studied histopathologically to detect different pathological changes. No significant morphological difference between both gases of the same concentration was detected. The changes were in the form of edema, hemorrhage and mild inflammatory infiltrate with sublethal doses; while with lethal doses, necrotic foci were detected in some organs