Histo-pathological, histo-chemical and ultrastructural changes of gastric mucosa in Egyptian patients with type C chronic active hepatitis [CAH]

ABSTRACT

Histopathological, histochemical and ultrastructural examinations of gastric mucosa were done in 20 cases with CAH post-virus C versus 20 healthy control individuals. The histopathological study of gastric mucosa in cases with type C CAH revealed chronic inflammatory cellular infiltrate with lymphocyte aggregation, hypoplasia of some glands with some cellular degeneration and an increase of fibrous tissues. There was a highly statistical significance between both groups regarding histopathological changes concerning histochemical changes of gastric mucosa in the diseased group. There was a highly statistical significant decrease of PAS positive-materials, succinic dehydrogenase and alkaline phosphatase stains and reactions, while there was a highly statistical significant increase of acidic phosphatase reaction as compared with the control group. The electron microscopic studies of gastric mucosa in cases with type C CAH revealed that oxyntic cells showed a decreased number of mitochondria with degenerative changes and peptic cells showing secretory granules, a decrease in the number of mitochondria, dilated endoplasmic reticulum and degenerative values