comparative study of the protective effect of some antidotes on the pancreas in Paraquat intoxicated rat

ABSTRACT

This study was conducted on 45 adult albino rats classified into four groups. Pancreatic sections were examined histologically by the routine stain H and E using LM and ultrastructurally by EM. Paraquat [PQ] intoxicated pancreas revealed massive degenerative and necrotic changes affecting both exocrine and endocrine parenchyma. By using Nath, the endocrine parenchyma was saved, while the exocrine one showed focal degenerative changes. On the other hand, deferoxamine [DF] showed a better protection than Nath as antidote for pancreatic PQ toxicity