Effect of cyproheptadine alone and in combination with aspirin on platelet aggregation

ABSTRACT

The antiplatelet effect of cyproheptadine was studied on platelet rich plasma [PRP] of 30 adult healthy human volunteers. It was compared with aspirin. Moreover, the combined effect of two drugs was also studied. The platelet aggregation [PA] was induced with adenosine diphosphate [ADP] and combination of 5-hydroxytryptamine [5-HT], and epinephrine. Cyproheptadine is found to be an inhibitor of PA. It is significantly more potent inhibitor of PA than that of aspirin [p < 0.001] in 5-HT plus epinephrine induced PA. It also has a synergistic effect with aspirin. Prophylactic therapy with combination of aspirin and cyproheptadine may be more beneficial in patients of occlusive vascular disease