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Surgical margins factors determining the extent of tumor resection in breast cancer patients treated by conservative surgery
Scientific Journal of Al-Azhar Medical Faculty [Girls] [The]. 2000; 21 (2): 109-126
in English | IMEMR | ID: emr-55502
ABSTRACT
A total of 102 female patients proven to have breast carcinoma was treated by modified radical mastectomy. Risk factors of local recurrence [tumor size, histological type and grade, presence of extensive intraductal component [EIC], vascular invasion and lymph node status] in addition to resection margins were examined. Immunohistochemical expression of adhesion molecule CD44 and prognostic marker C-erb B-2 were evaluated and correlated to the extent of tumor spread beyond the primary site. Tumor bed biopsies from the modified radical mastectomy specimens were taken at distances from 1-6 cm at six positions [anterior, posterior, lateral, medial, upper and lower] and examined for tumor extension. Risk factors of local recurrence in breast carcinoma [histological type, grade, EIC and lymph node status], in addition to adhesion molecule CD44 and prognostic marker C-erb B-2 should be considered in the selection of patients for conservative lumpectomy treatment and in determining the extent of surgical resection. A safety margin of 3 cm is considered to be sufficient in cases of invasive duct carcinoma without intraductal component
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Index: IMEMR (Eastern Mediterranean) Main subject: Recurrence / Immunohistochemistry / Biomarkers, Tumor / Oncogene Proteins / Oncogene Proteins v-erbB / Hyaluronan Receptors / Neoplasm Recurrence, Local / Neoplasm Staging Limits: Female / Humans Language: English Journal: Sci. J. Al-Azhar Med. Fac. [Girls] Year: 2000

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Index: IMEMR (Eastern Mediterranean) Main subject: Recurrence / Immunohistochemistry / Biomarkers, Tumor / Oncogene Proteins / Oncogene Proteins v-erbB / Hyaluronan Receptors / Neoplasm Recurrence, Local / Neoplasm Staging Limits: Female / Humans Language: English Journal: Sci. J. Al-Azhar Med. Fac. [Girls] Year: 2000