Splenectomy in donkeys with reference to the postoperative immune response and Phagocytic activity of neutrophils

ABSTRACT

The resent study clarify characteristic changes in serum protein fractions, immunoglobulin levels, and neutrophil phagocytic activity in splenectomized donkeys. The post-operative blood picture revealed a fluctuating tendency toward lymphocytosis and monocytosis. The electrophoretic pattern after splenectomy showed an elevation in albumin, Beta[1] and Beta[2] globulins and a fairly constant level in gamma globulins. Serum immunoglobulins, IgG, was significantly decreased 1-2 weeks after operation followed by a significant rise [3-4 weeks]. IgG [T], IgG and IgA levels were also significant lowered at different intervals after splenectomy. Preoperative antibiotic prophylaxis therapy was recommended for the control of overwhelming infection after splenectomy and for the decrease in the humoral immunity and defective phagocytic activity