Effects of trichloroacetate, water chlorination by-product, on liver peroxisomes and antioxidant status in rats and mice

ABSTRACT

Seven groups of each of male Fischer 344 rats and B6C3F1 mice were provided with drinking water containing distilled water 0.05 g/L trichloroacetate [TCA], 0.5 g/L TCA, 1.0 g/L TCA, 4.5 g/L TCA; distilled water + vitamin E and 4.5 g/L TCA + vitamin E, respectively, for 30 days. Liver palmitoyl Co-A oxidase [PCOA] and glycolate oxidase were estimated as peroxisomal enzymes. In addition, the liver content of water-soluble antioxidants, antioxidant enzymes and alpha- tocopherol were measured. These results demonstrated that the mouse is more sensitive than the rat with respect to the enhancement of liver peroxisome proliferation by TCA. A condition of oxidative stress produced by TCA exposure in drinking water was conducted. The possible role of oxidative damage in the hepatic carcinogenicity of TCA may be involved