Hyperhomocysteinemia and the risk of cardiovascular disease in hemodialysis patients and renal transplant receipients
Scientific Journal of Al-Azhar Medical Faculty [Girls] [The]. 2000; 21 (Supp. 1): 1055-1070
in English
| IMEMR
| ID: emr-55660
ABSTRACT
The aim of this work was to study serum total homocysteine [tHcy] in dialysis dependent end stage renal disease [ESRD] patients as well as in renal transplant recipients [RTR] in relation to the established cardiovascular disease [CVD] risk factors. The study included 20 ESRD patients on hemodialysis [HD, group I], 20 RTR [group II] as well as 15 healthy age and sex matched controls. In HD patients, the mean fasting tHcy was significantly higher than that of the controls and hyperhomocysteinemia occurred in 90% of the patients. In RTR, mean tHcy level was significantly lower than in HD patients, yet still significantly higher than the controls and hyperhomocysteinemia occurred in 60% of the patients. None of the studied CVD risk factors [blood lipids, smoking, and hypertension] was significantly correlated to tHcy. In RTR, tHcy was not correlated to blood cyclosporine trough level. It was concluded that hyperhomocysteinemia was a common characteristic of HD patients and a frequent finding in RTR. The results indicated that hyperhomocysteinemia was associated with the occurrence of cardiovascular disease in both patient groups as an independent risk factor
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Cardiovascular Diseases
/
Renal Dialysis
/
Kidney Transplantation
/
Kidney Failure, Chronic
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Sci. J. Al-Azhar Med. Fac. [Girls]
Year:
2000
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