Effect of xylene on the lung and other parenchvinatous organs in albino rats

ABSTRACT

Forty adult albino rats were divided into four groups, each included ten animals Group A served as a control, group B exposed to xylene vapors, group C was treated as group B but was housed in poorly ventilated cages and group D was treated as group B but left to recover for another two weeks, then decapitated. Group B showed signs of inflammation and cellular infiltration, especially in the lung which showed areas of hemorrhage and degeneration. The kidney and the heart showed areas of hemorrhage and scanty infiltration, while the liver did not show any morphological disorder. PAS technique showed a significant decrease in the mucopolysaccharides in the liver cells. These findings showed the various hazards of xylene. An occupational protection was highly recommended either by using safer alternatives or various barriers