[Lipoprotein [A] as a risk factor for coronary artery disease]

ABSTRACT

Lp[a] may represent a link between the fields of atherosclerosis and thrombosis. Elevated Lp[a] levels > 300 mg/l have been associated with the presence of atherosclerotic disease. This prospective study initiated in 1995 and, until June 1999 enrolled 218 subjects divided in two groups Gl subjects with / without angiographically proven coronary artery disease[CAD], n = 124 and Gll controls, n-94 The objective of this study was to assess the influence of high Lp[a] serum levels on the CAD. Secondary end point was to demonstrate a correlation between the level sevum Lp[a] and the severity of angiographic coronary findings, we found that the cases had significantly [p = 0.004] higher Lp[a] levels than the controls and that correlation existel between the value of Lp[a] serum levels and severity of angiographic findings. However, we do recommend Lp[a] screening for patients with curly CA 1] or a family history of CAD