Botulinum toxin A [BTX-A] for treatment of palmar hyperhidrosis

ABSTRACT

Palmar hyperhidrosis is a fairly common disease with an unknown etiology. Some treatment modalities have shown benefits, the most recent of which is the injection of botulinum toxin A [BTX-A]. We tried to test the beneficial effects of BTX [Dysport] in Iranian patients. Fifteen volunteers with severe palmar hyperhidrosis, diagnosed by iodine starch test, were enrolled in the study. Employing a standardized scheme, Dysport was injected intradermally into the palmar aspect of patients' dominant hands. The distal parts of the non-dominant hands were injected by normal saline as control. Follow-up was performed using iodine starch test. Wilcoxon signed rank test was used for comparison between the cases and controls. Satisfactory response to treatment was achieved in 13 out of 15 patients. Comparing the cases with the controls, Dysport showed a significant beneficial effect [p<0.001]. Weakness of handgrip was seen in 13 patients. We suggest using Dysport in the treatment of selected cases of severe palmar hyperhidrosis