Proteomics in human disease: awareness of new biomedical opportunities

ABSTRACT

Recent advances in biomedical technology have facilitated global analysis of cellular proteins and are termed as "proteomics". Proteomics has become the key area of research in biomedicine and microbiology which uses meticulous and sophisticated techniques including two-dimensional acrylamid gel electrophoresis, mass spectrometry and bio-informatic databases. Proteomics is rapidly growing into post-genomic era in biomedical investigations. Its base lies on structural, physical, functional and other bio-characteristics of proteins and its application provides great opportunity to clarify the action of various pathogenetic agents. It will identify new diagnostic methods, new diagnostic markers of disease, new therapeutic agents, as well as protein candidates for vaccines. Application of this phenomenon expands from basic research, to clinical applications such as drug development, control of infectious diseases, cancer, neuropathology and cardiovascular diseases