Synthesis and some reactions of -phenyl-B-9-anthroylpropionic acid

ABSTRACT

Reaction of Beta-9-anthroylacrylic acid [I] with benzene under Fried el-Crafts conditions gave the corresponding alpha-phenyl-Beta-9-anthroyl propionic acid [II]. Dehydration of II with Ac2O gave the butenolide III which reacts with amines to give anilides. IV. Condensation of II with hydrazines gave the corresponding hydrazones V and pyridazinone derivatives VI, and with hydroxyl-amine hydrochloride to give oxime VIII and dihydroxazinone derivative IX. Estrification of II using methanol and dry HC1 gave the methyl ester X. Reaction of X with hydrazines has been investigated