Multidrug resistant salmonella typhi in Gujranwala

ABSTRACT

One hundred and thirty strains of Salmonella typhi were isolated from the blood of patients clinically suspected to be suffering from typhoid fever for the 5-year period from Jan 1995 to Dec. 2000. The blood cultures were taken in brain heart infusion broth. The isolates were identified based on morphological, biochemical and serological characteristics. The susceptibility of the strains was tested by disc diffusion tests as per standard methods. A high level of resistance to first-line drugs was observed. 43.85 percent strains of S. typhi revealed resistance to chloramphenicol, 42.3 percent to ampicillin, 46.15 percent to co-trimoxazole, 37.69 percent to Amoxicillin, 6.15 percent to ciprofloxacin, 0.77 percent to pefloxacin, enoxacin, and ofloxacin. No resistance to ceftriaxone and cefotaxime was observed