Half life of Alprazolam in hepatic insufficient patients
Biomedica. 2001; 17 (2): 4-6
in English
| IMEMR
| ID: emr-56480
ABSTRACT
Alprazolam is a triazolobenzodiazepine which is primarily metabolized by the liver. To see its half life in hepatic insufficient patients tab. Alprazolam in a dose of 0.25 mg, B.D. was given orally to 15 such patients and 5 normal subjects taken as control. Drug was given for a period of 21 days to both groups. Blood samples were drawn at day 7 and 21. There was no remarkable change in half life on day 7 and 21, among control group. Same results were seen among hepatic group on both days but half life increased to about double on day 7 and 21, when compared to control ones. Thus, it was concluded that in hepatic insufficient patients, half life increases significantly due to alteration in hepatic biotransformation mechanism
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Triazolam
/
Liver Failure
/
Half-Life
/
Liver Diseases
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Biomedica
Year:
2001
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