Synthesis and anti-inflammatory activity of some thieno [2,3-d] pyrimidinone derivatives

ABSTRACT

3-amino-2,5,6-trimethylthieno [2,3-d]-pyrimidin-4[3H]-one [1] was reacted with anhydrides, isatins, isothiocyanates and isocyanates to obtain the pyrimidinone derivatives 2, 3 and 4, respectively. Cyclization of 3-N'-substituted-thioureas 4 with chloroacetyl chloride, substituted phenacyl bromides and malonic acid furnished thiazolidinones 5, thiazolines 6 and thioxopynmidin-4,6-dione 7, respectively. Representative members of these compounds were evaluated for their anti-inflammatory activity. It has been reported that some thieno [2,3-d] pyrimidinone derivatives exhibit anti- inflammatory activity. In addition, certain thiourea, thiazolidinone and thiazoline derivatives are well known as biological agents including anti-inflammatory action