Improved design for in-vitro measurement of adhesion parameters of bioadhesive pharmaceutical systems

ABSTRACT

A simple apparatus was designed to measure the adhesion parameters, the detachment force and the work of adhesion, for solid and semisolid bioadhesive dosage forms. Validation of the new design using natural and synthetic bioadhesives showed that the system gave reproducible results. Two model membranes, the bovine cheek membrane and the bovine intestine, were tested as the biological platform using carbopol 934/HPMC systems in the ratios [1000, 9010, 5050]. The bovine intestine gave more reproducible results than the bovine cheek membrane. Carbopol 974p/HPMC and carbopol 974p/HPC are the systems used to determine the effect of contact time on the adhesion parameters and to confirm the linear relationship between the detachment force and the work of adhesion