Preparation and physicochemical characterization of solid dispersions of piroxicam with phospholipids

ABSTRACT

Solid dispersions of piroxicam with dimyristoylphosphatidylcholine [DMPC], dipalmitoylphosphatidylcholine [DSPC] and distearoylphosphatidylcholine [DSPC] in ratios of 201, 101 and 51 [drug-to-phospholipids w/w], were prepared by the solvent evaporation method. Coprecipitation was done from a chloroform solution of the appropriate quantities of piroxicam and each phospholipid according to the previously mentioned w/w ratios. The physicochemical characteristics of piroxicam-phospholipids coprecipitates were evaluated using differential scanning calorimetric analysis [DSC], X- ray diffraction analysis [XRD] and Fourier transform infrared analysis [FTlR]. Results were compared with the pure drug and the corresponding physical mixtures in the same weight ratios