Enhancement of dissolution and bioavailability of firoxicam via solid dispersion with phospholipids
Bulletin of Faculty of Pharmacy-Cairo University. 2001; 39 (1): 309-20
in English
| IMEMR
| ID: emr-56552
ABSTRACT
In this work physical mixtures [PMs] and coprecipitates [COPPTs] of piroxicam [PIR] with each of L-alpha-dimyristoylphosphatidylcholine [DPPC] and L-alpha-distearoylphosphatidycholine [DSPC] in ratios of 201, 101 and 51 [drug-to-phospholipids w/w] were prepared. The effect of the method of preparation, the type of phospholipids [PL] and the drug-to-PL w/w ratios on the rate and extent of dissolution of PIR was investigated. The effect of the previously mentioned factors on the dissolution efficiency [DE%] was analyzed using two-way analysis of variance [ANOVA]. The most significant effect on the dissolution rate and extent was due to the method of preparation followed by the drug-to-PL ratio and finally the PL type. All PIR-PL systems improved the dissolution rate of piroxicam, but coprecipitates of 51 w/w ratio showed the superior effect on the drug dissolution profile
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phospholipids
/
Solubility
/
Pharmaceutical Preparations
/
Biological Availability
/
Anti-Inflammatory Agents, Non-Steroidal
Language:
English
Journal:
Bull. Fac. Pharm.-Cairo Univ.
Year:
2001
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