Design and evaluation of a new dry powder inhaler.
DARU-Journal of Faculty of Pharmacy Tehran University of Medical Sciences. 2001; 9 (3-4): 46-9
in English
| IMEMR
| ID: emr-56608
ABSTRACT
Three versions of a new dry powder inhaler [DPI], RG-haler, were designed using two kinds of grid inserts. Salbutamol sulfate/lactose blend [Ventolin Rotacaps[R]] was selected as a model formulation to analyze the performance of all inhalers and compare their efficiency with three marketed devices [Rotahaler[R], Spinhaler[R] and ISF inhalator[R]] using the twin impinger [TI]. Deposition of the drug in device was significantly [P<0.05] lower for ISF inhalator[R] and all kinds of RG-halers in comparison with those of Rotahaler[R] and Spinhaler[R]. The amount of drug deposited in the stage 2 and the respirable dose for RG-halers were similar to those of ISF inhalator[R] and significantly [P<0.05] higher than those of Rotahaler[R] and Spinhaler[R]. The results suggest efficient aerosol generating capability of the RG-haler
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Powders
/
Administration, Inhalation
/
Albuterol
Language:
English
Journal:
J. Fac. Pharm. Tehran Univ. Med. Sci.
Year:
2001
Similar
MEDLINE
...
LILACS
LIS