Effect of rifampicin as enzyme-inducing agent on some fertility parameters of male ablino rats

ABSTRACT

The effect of rifampicin " as enzyme-inducing agent " at intraperitoneal dose [25 mg/kg body wt.] for 3 successive months on plasma testosterone level and some seminal parameters were studied in adult male rats. Plasma testosterone concentration was significantly increased at the end of the 1[st] 2[nd] and 3[rd] month of rifampicin administration. An improvement in sperm cell concentration and sperm motility% were also recorded. The results of the present study indicate that rifampicin "as enzyme-inducing agent" may have an improvemental effect on some male fertility parameters which might be due to induction of testosterone biosynthesis and/or an increase in sex hormone binding globulin [SHBG] level