Effect of hormone treatment on the uptake of horseradish peroxidase by the brain and spinal cord in female rats

ABSTRACT

Training different animal groups of the female rat with the hormones testosterone, oestradiol, hexoestrol, progesterone, hexoestrol [+] progesterone and cortisone, facilitated the uptake of HRP by the brain and spinal cord. The hormones were applied-dissolved in sesame oil-daily for four months. The doses daily injected [s.c.] were 40, 50 and 10 micro g/100 g body weight of testosterone, oestradiol and each other hormone respectively. HRP [14.137 mg/100 g .body weight] was injected [i.v.] one, two and six hours pre the assay. The uptake of HRP by the brain and spinal cord depended on B-BB dysfunction and/or the process of pinocytosis. In addition the quantity of HRP taken b/ the brain and spinal cord varied according to the applied hormone, the time of circulation of HRP and the investigated tissue