Quantitative assessment of salivary gland function by radioisotopic scanning in a randomized trial of pilocarpine for prevention of radiation induced xerostomia
Iranian Journal of Nuclear Medicine. 2001; (14-15): 11-20
in Persian
| IMEMR
| ID: emr-56916
ABSTRACT
Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Patients randomized in placebo-controlled trial of pilocarpine concurrent with irradiation for prevention of radiation-induced xerostomia were evaluated by salivary gland scintigraphy immediately before and 6 months after the end of head and neck radiotherapy. Salivary gland function was measured by ejection fraction [EF] of Technetium-99m pertechnetate. The mean values for pre and post-radiotherapy scans were calculated and compared. Also post-radiotherapy scan findings in the two groups of pilocarpine and placebo were compared using the student's t-test. In addition, comparison was made between the scan results and the subjective findings and objective gradings. Twenty patients underwent the pre-radiotherapy salivary scintigraphy, and also 20 post-radiotherapy scans were performed. Mean parotid EF was 60.85% in the pre-radiotherapy and 9.08% in the post-radiotherapy scans [P<0.01]. The means for submandibular glands in the pre and post-radiotherapy scans were 41% and 11.2%, respectively [P<0.01]. Also the mean EF was 14.5% in the pilocarpine group and 3.65 in the placebo group for parotid glands [P=0.07] and 18.3% and 4.1% respectively for submandibular glands [P<0.05]. The salivary scans confirmed the subjective and objective xerostomia findings. Salivary gland scintigraphy is a valuable method for evaluation of xerostomia after head and neck radiotherapy, quantitatively demonstrating the protective effect of pilocarpine compared to placebo on salivary glands
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Pilocarpine
/
Radiation Effects
/
Salivary Glands
/
Radionuclide Imaging
/
Randomized Controlled Trials as Topic
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Persian
Journal:
Iran. J. Nucl. Med.
Year:
2001
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