Fibrocystic diagnosis of solid breast lump fine needle cytology need true cut biopsy to rule out malignancy

ABSTRACT

This study aimed at identifying the reasons for the false negative of fine needle aspiration cytology in the pre operative diagnosis of breast cancer. A prospective study involving 160 women with palpable breast lump studied by ultrasound and or mammogram, fine needle aspiration and core biopsy. There were 6 cases of false negative results by fine needle aspiration; 5 diagnosed as fibrocystic, 4 of them turned out later to belobular carcinoma, and one as infiltrating ductal carcinoma. One diagnosed as atypical cells turned out later to be lobular carcinoma, There was one false negative result by the core biopsy, which diagnosed as fibrocystic disease and turned out later to be lobular carcinoma. In all false negative cases was found associated with fibrocystic disease. We concluded that the presence of fibrocystic disease may mask a malignancy. Fine needle aspiration cytology is no more dependable in reassuring patients with solid breast lump diagnosed as fibrocystic disease. Core biopsy was more helpful in diagnosing lobular carcinoma and in ruling out malignancy infibrocystic disease