Studies on patients with Schistosomiasis mansoni, HCV and/or typhoid fever

ABSTRACT

This study was carried out on two groups of patients The first one included 50 Schistosomiasis mansoni patients [30 with simple infection, ten with splenomegaly and ten with ascites] and the second group included 111 patients of whom 20 with pure S. Manson, 27 with pure HCV infection, 54 with mixed infection of schistosomiasis and HCV and ten with schistosomiasis, HCV and typhoid fever. Serum transaminases and anti-HCV antibodies performed showed anti-HCV raised levels in 10% of simple schistosomiasis, 60% in splenomegalic patients, 80% in ascites patients and 7.1% in the controls. Liver function tests in the first group were within the normal range except in those with ascites. In the second group, liver function tests were normal in pure schistosomiasis patients. In pure HCV patients, serum bilirubin was normal in 22.2% and AST, AET and alkaline phosphatase were higher. In mixed infection; serum bilirubin was normal in 18.5%, serum transaminases were higher and alkaline phosphatase was normal among 77.7%. Patients with typhoid fever, HCV and schistosomiasis showed a significant increase of liver function as compared with each of pure HCV or HCV and schistosomiasis