Soluble adhesion molecules versus lymphoblast transformation in diagnosis of zoonotic cutaneous leishmaniasis

ABSTRACT

Twelve parasitologically proven ZCL patients [one with non-ulcerative lesion and eleven with multiple ulcerative lesions] were subjected to estimation of the levels of lymphoblast transformation [LTT] and soluble adhesion molecules [sICAM-1and sELAM-1 by ELISA]. The results proved high percentage of LTT in relation to number and clinical picture of the ZCL lesions. As to the soluble adhesion molecules, s ICAM-1 levels were significantly increased than in normal controls and correlated positively with the number of ulcerative lesions. s ELAM-1 levels were not significantly increased than the normal controls but correlated positively with the number of ulcerative lesions. Consequently, soluble adhesion molecules mainly s ICAM-1 is a good marker of endothelial damage in ZCL as related to number and clinical type of lesions