Efficacy, safety and tolerability of psyllium hydrophilic mucillpod in mild to moderate hypercholestrolemia

ABSTRACT

Coronary heart disease is the leading cause of death. Hypercholesterolemia and specially increased LDL cholesterol is the major risk factor in coronary heart disease. Psyllium hydrophilic mucilloid [PHS] is used for decades as laxative agent for the treatment of constipation. Now its role in reducing cholesterol level is well established. We used PHS as adjunctive to low fat diet and we found it effective, safe and well tolerable in patients with mild to moderate hypercholesterolemia. Psyllium [PHS] 3.4 G three times daily as adjunctive to low fat diet reduced total cholesterol and LDL cholesterol by 12.1% and 20.8% with mild transient gastrointestinal disturbances