Effects of antihypertensive drug captopril on the metabolism in hypertensive NIDDM patients

ABSTRACT

Ten hypertensive diabetic patients with type 11 diabetes were treated with tablet captopril 25 mg twice a day for 5 weeks. It belongs to the class of angiotensin converting enzyme inhibitors. In these patients mean fasting blood glucose level decreased by 29.04% [P<0.01], plasma insulin level increased by 124.3% [P<0.01], serum cholesterol decreased by 22.56% [P<0.05], serum triglycerides decreased by 3.04% [P=non-significant], HDL-cholesterol increased by 23.46% [P<0.01], LDL cholesterol and VLDL cholesterol decreased by 2.68% [non-significant] and 3.04% [non-significant] respectively. Plasma fibrinogen level decreased by 14.46% [P<0.05]. Both the systolic and diastolic blood pressure showed highly significant decrease [P<0.001]. Weight and body mass index showed non-significant results. The administration of captopril appeared to be not only an effective way of lowering the blood pressure in hypertensive diabetic patients but it also have exerted beneficial effects on the carbohydrate, fats and protein metabolism