Comparison of plasma protein concentration and haematological parameters in type-1 and type-2 diabetics of short and long duration

ABSTRACT

Diabetes mellitus is the most common metabolic disorders, characterized primarily by relative or absolute insufficiency of insulin secretion and concomitant insensitivity or resistant to the metabolic action of insulin on target tissues leading to metabolic derangement. These metabolic derangements are translated into alteration in blood constituents, thus affecting the characteristic of blood. The purpose of this study was to evaluate hematological and biochemical parameters in blood of diabetics of short and long term duration. Hematocrit, ESR, serum sugar, fibrinogen, total serum protein, albumin, and globulin were determined in shortand long-term type-1 and type-2 diabetics, and in healthy control subjects. Hematocrit, ESR, serum sugar, fibrinogen, total serum protein, and albumin concentration of both short- and long-term type-1 diabetics were significantly greater than those of the non-diabetics controls. There were no significant differences between short- term type-2 diabetics and the controls in the parameters like hematocrit, ESR, fibrinogen and globulin. However, hematocrit, ESR, serum glucose, fibrinogen, total serum protein, and albumin of long-term type-2 diabetics were significantly elevated above those of the controls. Based on the reported association of these parameters with diabetic complications, our results suggest that there could be an earlier development of complications in type-1 than in type-2 diabetics