Treatment of male subfertility with FSH in intrauterine insimination: a randomized study

ABSTRACT

A prospective randomized study was performed in 148 couples undergoing IUI because of male Subfertility. In the treatment group, 150 IU FSH were administered IM to the husbands, three times a week, starting 3 months before the beginning of IUI cycles and maintained until the fifth IUI cycle. In the control group no treatment was given. The pregnancy rate per cycle was 13.5% in the FSH group versus 10% in the non-FSH group. The pregnancy rate per woman was 44.4% in the FSH group versus 37% in the non-FSH group. This means that the pregnancy rate increase was > 30% per cycle and >20per woman in the FSH group. The cumulative pregnancy rate was 59.2% in the FSH group versus 42.9% in the non-FSH group. The pregnancy rate outside the IUI cycles was 14.7% in the FSH group versus 2.5% in the non-FSH group|