Values of biochemical markers: triglycerides, lipoproteins and apolipoproteins in the early pathogenesis of coronary arteries atherosclerosis

ABSTRACT

Blood lipid and lipoprotein values were analyzed in 42 male cadavers aged from 20-50 years old who died suddenly and unexpectedly without any cardiac history antecedent to death. All cases were selected from those who died and referred to the Morgue of Forensic Medicine Department, Criminal Evidence, Ministry of Interior, Kuwait, during the period between August 1999 and July 2000. A total number of 30 adult male subjects who died from non-cardiac causes were used as a control group. A statistical significant difference was found between the two studied groups as regards age, total cholesterol [T-Chol], triglycerides [TG], low density lipoprotein [LDL], high density lipoprotein [HDL], Apo A1, Apo A11 lipoproteins and Apo B lipoprotein. Also, a significant difference in the degree of narrowing of coronary arteries was found. Among the cardiac group, TG, HDL, LDL, Apo A1, Apo B parameters were found to be an effective biochemical markers when coronary arteries narrowing exceed 50%. Furthermore, using multiple logistic regression of significant risk factors that predict coronary atherosclerosis showed that high density lipoprotein [HDL] and Apo B were a significant risk predictor