Lead modulates T lymphocyte functions in albino rats
MJFCT-Mansoura Journal of Forensic Medicine and Clinical Toxicology. 2001; 9 (2): 141-150
in English
| IMEMR
| ID: emr-57787
ABSTRACT
The present work was performed to study the effects of subchronic and chronic in vivo exposure to lead on some parameters of T lymphocyte functions; namely, interferon-gamma [IFN-gamma] production and mitogen blastogenesis in albino rats. Adult female albino rats, with body weight range of 150-250 g, were randomized into test and control groups, 20 rats/group. Test groups were treated with lead acetate solution in distilled water by intraperitoneal injection at two dose levels [20 mg/kg body weight or 40 mg/kg body weight for either 4 weeks or 12 weeks for each dose level]. Control groups were treated with distilled water by intraperitoneal injection for either 4 weeks or 12 weeks. The results showed that lead exerted immunomodulatory effects on the studied immune parameters. It decreased gamma-IFN serum levels and enhanced blastogen transformation of lymphocytes in a dose and time-dependent manner. These results showed that lead differently affects T cell subpopulations. Dysregulation of the immune function may be the end result:
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
T-Lymphocytes
/
Interferon-gamma
/
Immune System
/
Mitogens
Limits:
Animals
Language:
English
Journal:
Mansoura J. Forensic Med. Clin. Toxicol.
Year:
2001
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