Assessment of some acute phase proteins and C-erb B-2 in schistosomal infected and bladder cancer patients in Egypt

ABSTRACT

The present study included 54 cases suffering from bladder cancer, 21 cases of schistosomal patients and 9 healthy control subjects. Urinary bladder tissues of the selected diseased groups were subjected to immunohistochemical identification of C-erb B-2. Alpha-1- antitrypsin [AlAT], haptoglobin [HP], alpha-2- macroglobulin [alpha-2-MG], retinol binding protein [Rbp] and transferrin [TRP] were measured in serum of all investigated groups. Tissue samples were taken from 68 bladder cancer patients, 32 cases were positive for immunostaining of C-erb B-2 and 35 cases showed negative immunostaining. There was a significant increase in the mean serum levels of AlAT of bladder cancer patients as compared with control and schistosomal patients. The levels of HP were significantly increased in both schistosomal and bladder cancer patients as compared with control group. On the other hand, there were no remarkable differences in the levels of alpha-2-MG. Rbp and TRF were observed between the three investigated groups. Nevertheless, there was significant increase in serum level of alpha-2-MG for both grades II and III as compared with grade I. Also, significant differences were recorded in the mean serum levels of TRF between the two histopathological types; namely, squamous cell carcinoma [SCC] and transitional cell carcinoma [TCC]