Effects of the major parameters affecting the clot formation

ABSTRACT

The effects of the major parameters affecting the clot formation such as time, temperature, and flowrate are investigated using a constant-low machine of a closed loop-circuit type. Furthermore, the effects of adding different concentrations of [heparin] as anticoagulant; capramol and [trasylol] are also investigation both stationary tanks and agitated tanks in addition to the closed loop-circuit of constant flow. The following relations were deduced from the results of this study I] W[c] = 35.995 W[0.01 z]/ j[0.052] T [1.23] L[0.Iz6] where w[e] is the weight ratio of the clot. J is the time, t is the temperature, w is the angular velocity. L is the flowrate. Although the injection of heparin at low concentrations [below 5000 units / body] has no effect, yet at high concentrations [in the range of 15000, 20000 and 25000 units/adult body] heparin acts as fibrinolytic drug. Also it is shown that both [capramol] and trasylol reveal fibrinolytic activity, which is attributed to their known inhibitory action to plasmin