Plasma thrombomodulin levels in patients with chronic renal failure

ABSTRACT

To evaluate the plasma soluble thrombomodulin T M levels in patients with chronic renal failure on conservative treatment and in those on hemodialysis as a new marker which reflect the extent of endothelial dysfunction with possible relation to cardiovascular complications Forty two patients with chronic renal failure together with twenty normal control subjects were allocated to this study. Patients were divided into two groups group I of twenty patients on conservative treatment and group II of twenty two patients on hemodialysis treatment. Patients with diabetes mellitus, collagen vascular diseases, haemorrhagic diathesis and with malignancies were excluded from this study. There was significant increase in mean plasma TM levels in each group compared with normal subjects [p<0.05, p < 0.01 respecitvely]. Throm-tenodulin level was positively correlated with duration of chronic renal failure [p < 0.05]. Also, there was a positive correlation between plasma TM levels and duration of hypertension in both groups [p < 0.05; p<0.01]. Also these results may suggest that TM level can be considered as a marker for extent of endothelial damage and can reflect cardiovascular morbidity in patients with chronic renal failure