relation between esophageal motility disorders glycemic control in type II diabetes mellitus

ABSTRACT

Reduced values all of lower esophageal sphincter [LES] pressure, LES relaxation percentage, LES relaxation percentage, esophageal body contraction duration, velocity of waves in the esophageal body and pharyngeal pressure were noted in the diabetic patients when compared with the controls. Also, triple peaks as well as retrograde and spontaneous contractions were more frequently encountered in the diabetics. Uncontrolled diabetics showed reduced LES pressure, more prolonged esophageal contraction duration, more frequent triple peak and retrograde contraction than controlled ones. There were statistically significant negative correlations between fasting blood sugar and LES pressure and statistically significant direct correlations and retrograde contraction percentage, spontaneous contraction and pharyngeal pressure. There were statistically significant negative correlations between glycated hemoglobin and LES pressure and esophageal body contraction amplitude. It was concluded that poor glycemic control seems to adversely affect the esophageal motility parameters in patients with type II diabetes irrespective of autonomic abnormalities