Influence of capsaicin on drug absorption and transport across biological membranes II Effect on gastrointestinal absorption of sulfamethazine sodium in rats

ABSTRACT

The gastrointestinal absorption of sulfamethazine sodium in rats was studied in presence and in absence of capsaicin. The absorption was evaluated by the pharmacokinetic analysis of the plasma levels of sulfamethazine following its oral administration. Capsaicin was found to increase the rate constant of absorption and the AUC of the plasma levels versus time, without changing the rate constant of elimination