Role of vitamin [E] against immunotoxic and genotoxic effects of hexavalent chromium in albino rats

ABSTRACT

Sine chormium is one of the most important pollutants present in the general and industrial environment that induce health hazards, it was the aim of the present study to shed light on the role of antioxidant as vitamin [E] in the protection against immunotoxic and genotoxic effects of chromium in adult albino rats. Rats were divided into four groups, the first group was given 1/10 LD 50 of sodium dichromate, the second group was given sodium dichromate with vitamin E, the third group was given vitamin E alone in addition to the control group as a fourth group. After three weeks serum immunoglobulin [IgG and IgM] with immunohistochemical change in T-lymphocytes in bone marrow and spleen were detected and chromosomal pattern in rats bone marrow were examined. Results showed a significant decrease in serum immunoglobulin [IgG and IgM] and decrease in the number of CD4 helper T-lymphocytes with some increase in the number of CD8 supressors T-Iymphocytes and abnormalities in chromosomal pattern in the first group while the other groups showed no changes in serum immunoglobulins, T -lymphocytes or chromosomal pattern vitamin E administration can be a promising solution to ameliorate the chromium-induced immunotoxic and genotoxic effect. So, further studies on individuals exposed to chromium regarding its immunotoxicity and genotoxicity is recommended