Ondansetron and tramadol for the treatment of post-extradural shivering

ABSTRACT

Sixty patients suffering from post-extradural shivering were randomly divided into three equal group. Group I, each patient received intravenous [IV] 0.5 mg /kg tramadol, and in group II, each patient was given 0.1 mg /kg IV ondansetron. while group III patients, received IV saline. The efficacy of both drugs on suppression of post-extradural shivering was compared. Onset at effect, the response rate and arrest time of shivering, heart rate, mean arterial pressure, blood gas changes, the level of plasma catecholamines and the incidence of adverse effects including recurrence of shivering were evaluated. Ondansetron could be considered an effective alternative to tramadol in aborting post-extradural shivering with high safety profile and no adverse effect