Trials of some antibiotics and chemotherapeutics on experimental trichinosis

ABSTRACT

Four drugs were tested for their effect on the intestinal and/or the muscle phase of Trichinella spiral is in rats. Thiabendazole was the most effective during the intestinal phase. Mebendazole reduced the number of larvae. Rifampicin and bleomycin had a weak action on larval count. Histopathological findings confirmed the previously mentioned results. During the muscle phase, all drugs were found to be ineffective except bleomycin which showed a mild effect on larval viability