Neurotoxicological effects of steroidal compounds in changes of cholesterol level on albino rat brain

ABSTRACT

Changes in the level of cholesterol in albino rat brain [cerebrum hemisphere, cerebellum and brain stem] were evaluated following the administration of four steroidal derivatives as 3 beta-Acetoxy-5-bromo 6-beta succinimido, 5 alpha-cholestane A[I], 3 beta-chloro-5-bromo 6 beta-amino-5 alpha-cholestane B[II], 3 beta-Acetoxy-6-phthalimid choloest-5-ene C[III] and 6-nitro cholest 5-eno [3 alpha-4 alpha-d] oxazolidin-2-one D[IV]. Experiments were carried out on four groups of six male albino rats weighing 200 +/- 20gm. Control rats were administered normal saline water intraperitoneally [ip] while the other experimental groups were given 0.3 mg/kg bodyweight of steroidal solution which was prepared in peanut oil