Helicobacter pylori seropositivity among patients with hyperemesis gravidarum

ABSTRACT

There are also reports from other parts of the world indicating the presence of significant association of H. pylori infection and hyperemesis gravidarum, a bothersome condition that affects pregnant women. To test the hypothesis that whether H. pylori infection is associated with hyperemesis gravidarum among Iranian H.P carriers. From November 1999 to February 2001, we enrolled 54 pregnant women with hyperemesis gravidarum and 53 asymptomatic pregnant women [control group] in a prospective study. Using a specific serum IgG against H. pylori, the seroprevalence of H. pylori infection was determined in both study and control groups. Serologically positive H. pylori infection was detected in 44 [82%] out of 54 patients with hyperemesis gravidarum and 29 [55%] out of 53 asymptomatic pregnant women. The prevalence was significantly [p<0.01] higher in those with hyperemesis gravidarum than those in the control group. The mean SD of the IgG titer in the study group [69.7 77.5] was significantly [p<0.01] more than that of the control group [34.5 47.8]. H. pylori infection may cause hyperemesis gravidarum